mTORC1: Key Regulator of Cell Growth and Metabolism (P12327)

Target Name: mTOR complex 1

NCBI ID: P12327

mTOR complex 1

Other Name(s): mTORC1 | mTORC1 complex

mTORC1: Key Regulator of Cell Growth and Metabolism

The mTORC1 complex is a key regulator of cell growth and metabolism in eukaryotic cells. It is composed of the protein mTOR (mechanistic target of rapamycin), the protein rictor, and the protein speaker. mTORC1 plays a crucial role in the regulation of cell growth , protein synthesis, and stress response.

The mTORC1 complex is activated by signals from various cellular stressors, including nutrient deprivation, mechanical stress, and hormonal changes. Activation of mTORC1 leads to a series of downstream signaling pathways that ultimately result in the inhibition of cell growth and the regulation of cellular processes such as cell division, differentiation, and stress response.

One of the key functions of mTORC1 is the regulation of protein synthesis. The mTORC1 complex is responsible for the translation of mRNAs into proteins. It does this by binding to specific promoter region of target mRNAs and ensuring that the necessary factors for protein synthesis are available. mTORC1 also regulates the localization of the rRNA component of the mTOR complex to the nucleolus, where rRNA synthesis is initiated.

Another important function of mTORC1 is the regulation of stress response. mTORC1 is involved in the regulation of cellular stress response by activating the stress-responsive protein p70. Activated p70 can interact with the transcription factor p21 and induce the expression of genes involved in stress response . This gives mTORC1 a role in the regulation of cellular stress tolerance.

The mTORC1 complex is also involved in the regulation of cell growth. mTORC1 is known to inhibit the growth-promoting protein S6. This protein plays a role in the regulation of cell cycle progression and is involved in the development of cancer. mTORC1 can also promote the degradation of the negative regulator of the cell growth protein, p70. This allows mTORC1 to promote cell growth and proliferation.

In addition to its role in protein synthesis and stress response, mTORC1 is also involved in the regulation of cell division. mTORC1 is known to promote the association of the transcription factor YAP with the positive regulator of DNA binding, p21. This allows mTORC1 to regulate the association of YAP with its downstream target, p53. p53 is involved in the regulation of cell cycle progression and is a known regulator of apoptosis.

The mTORC1 complex is a complex protein that plays a crucial role in the regulation of cellular processes in eukaryotic cells. Its downstream signaling pathways are involved in the regulation of cell growth, protein synthesis, stress response, and cell division. potential drug target and may be a biomarker for various diseases.

Protein Name: MTOR Complex 1

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